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March 2016

Volume 2  Issue 1

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Research Article

Integrating D-dimer Levels in Revised Wells Score to Improve the Clinical Prediction of Pulmonary Embolism

Olga Derzec, Simona Croitoru, Yaniv Dotan*, Elad Schiff, Arie Oliven

The clinical signs and symptoms of pulmonary embolism (PE) PE are often non-specific, rendering the decision whether a more detailed diagnostic work-up to exclude PE is needed highly individual and subjective. Several large prospective studies were performed to provide objective scoring to guide and support the clinical decision. Unfortunately, none of the scoring systems was found superior to the decision of an experienced physician.

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Case Report

A case report of Pulmonary Capillary Hemangiomatosis: Rapid Deterioration after Diagnosis with Unsuccessful Response to Doxycicline Therapy

Kanacri Andrés I, Castro Pablo F*, Baraona Fernando E, Baeza Cristián R, Bourge Robert C, Bustamante Andrea P

Pulmonary capillary hemangiomatosis is an extremely rare cause of Pulmonary Arterial Hypertension. It is characterized by an uncontrolled proliferation of endothelial cells affecting thin walled micro vessels that invade lung parenchyma, the bronchial walls and the adventitia of larger vessels. This process leads to pulmonary arterial hypertension, hemoptysis and right heart failure, followed by death. Most cases have been confirmed with necropsy and the only effective treatment is bilateral lung transplant. We present a case of a young female patient affected by a rapidly progressive form of this disease.

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Research Article

Seeking Biomarkers in Differential Diagnosis of Pleural Effusion: the Contribution of Measurements of Glycosaminoglycan, Cathepsin s, Cathepsin H and Vascular Endothelial Growth Factor 

Nalan Göloğlu, Cengiz Özge, Gürbüz Polat, Serin Akbayır, Bahar Taşdelen, Eylem S Özgür*, Sibel Naycı Ahmet İlvan

Pleural effusion is a frequently encountered problem in clinical practice. Cathepsin S and cathepsin H are produced by mesothelial cells located in the pleural cavity and play a role in the activation of acquired immune response. Vascular endothelial growth factor (VEGF) and glycosaminoglycans (GAGs) are known as the indicators of local inflammation and pathological development.

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Research Article 

The Change in Pulmonary Function among Well-Controlled Mild Asthmatics after Initiation of Inhaled Corticosteroids 

Yasuaki Masaki, Hirokazu Taniguchi*, Tomomi Ichikawa, Kazuki Shimokawa, Takeshi Tsuda, Hideaki Furuse, Kensuke Suzuki, Ryuji Hayashi, Kazuyuki Tobe

Asthma is characterized by variable airway narrowing, which is the cause of symptoms and physiological changes. Several studies have shown that asthma can lead to permanent airway obstruction and that asthmatics experience a more accelerated decline of forced expiratory volume in one second (FEV1) than normal subjects. Airway remodeling may be associated with an increased rate of decline in lung function among patients with asthma. However, an accelerated decline of pulmonary function does not occur in all asthmatics. The prevalence of and factors associated with the accelerated decline of pulmonary function in patients with asthma are not fully elucidated.

         

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